Destroy completely; damage irreparably.
You have ruined my life.
You have ruined my car by pouring sugar in the tank!+ More
An irrecoverable state of devastation and destruction.
You have brought ruin on this entire family.
Burn, Burn Down, Fire - destroy by fire.
Desolate, Devastate, Lay Waste To, Ravage, Scourge, Waste - cause extensive destruction or ruin utterly.
Do A Job On - destroy completely or make ugly or useless.
Grandeur, Magnanimousness, Nobility, Nobleness - the quality of elevation of mind and exaltation of character or ideals or conduct; "He wins you over by his nobleness".
Call, Name - assign a specified (usually proper) proper name to; "Who named you ?".
You - Used to refer to the one ; "What have you named him ?".
Something - An undetermined or unspecified thing; "There is something in these eyes".
Annoy, Bother, Chafe, Devil, Get At, Get To, Gravel, Irritate, Nark, Nettle, Rag, Rile, Vex - cause annoyance in; disturb, especially by minor irritations; "Didn`t she irritate you ?".
Farther, Further - to or at a greater extent or degree or a more advanced stage (`further` is used more often than `farther` in this abstract sense); "Don`t annoy me further".
Incorrect, Wrong - not correct; deviating from truth or fact; "What have I done wrong to you ?".