Destroy completely; damage irreparably.
You have ruined my life.
You have ruined my car by pouring sugar in the tank!+ More
An irrecoverable state of devastation and destruction.
You have brought ruin on this entire family.
Burn, Burn Down, Fire - destroy by fire.
Desolate, Devastate, Lay Waste To, Ravage, Scourge, Waste - cause extensive destruction or ruin utterly.
Do A Job On - destroy completely or make ugly or useless.
Compulsion, Obsession - an irrational motive for performing trivial or repetitive actions, even against your will; "Understand my compulsion".
Despair - lose heart; give up hope; lose courage; "Don`t despair, I`m with you!".
Despair, Desperation - a hopeless state; "She cried in despair when Amit forsook her".
Reasonable, Sensible - showing reason or sound judgment; "You seem sensible".
When - At what time used interrogatively; "Since when have you been so nice ?".
Ignorant, Unknowing, Unknowledgeable, Unwitting - unaware because of a lack of relevant information or knowledge; "an ignorant child is chewing the power cable".