Destroy completely; damage irreparably.
You have ruined my life.
You have ruined my car by pouring sugar in the tank!+ More
An irrecoverable state of devastation and destruction.
You have brought ruin on this entire family.
Burn, Burn Down, Fire - destroy by fire.
Desolate, Devastate, Lay Waste To, Ravage, Scourge, Waste - cause extensive destruction or ruin utterly.
Do A Job On - destroy completely or make ugly or useless.
Forbearance, Longanimity, Patience - good-natured tolerance of delay or incompetence; "There is a limit to the patience".
Water - a liquid necessary for the life of most animals and plants; "Do I bring water ?".
Avoirdupois, Blubber, Fat, Fatness - excess bodily weight; "You will get fat".
Job, Problem - a state of difficulty that needs to be resolved; "Have you got any problem ?".
Perusal, Perusing, Poring Over, Studying - reading carefully with intent to remember; "She fell asleep while studying".
Betray, Deceive, Lead Astray - cause someone to believe an untruth; "You have betrayed me".
Betray, Sell - deliver to an enemy by treachery; "Army commander betrayed his country".